In 2003, after winning the Felinas beauty pageant in São Paulo, Souza and Antonela Avellaneda (first runner-up) starred in the November issue of Playboy magazine as "As Felinas" (The Felines). Souza gained fame playing the role of "Mulher Samambaia" (Fern Woman) in the pilot show of Pânico na TV, a satire consisting of beautiful women who stand on stage just to grace the scenery. After making regular appearances on the show, she gained attention in the modelling world.
Shortly after her departure from Pânico na TV in 2009, Souza was a favorite contestant in the first season of the reality show A Fazenda.
She owns the brand Zami Concept and maintains several company stores.
Souza was on the cover of the magazine Sexy in December 2004 and August 2007.
As of June 2024, she has amassed 1.5 million followers on Instagram and 531,000 subscribers on her YouTube platform.