Jessica St. Clair was born on September 21, 1977 in Westfield, New Jersey, United States.
She completed her degree from Middlebury College.
She started her acting career onscreen in the early 2000s, first appearing in The Colin Quinn Show in 2002.
Her first recurring role on television was as Sarah in Worst Week (2008-2009). Subsequently, she landed a regular role in the short-lived sitcom In the Motherhood.
She continued her prolific career on the small screen with recurring roles in Weeds, Love Bites, Veep, Review, The McCarthys, and Marry Me.
In 2014, she began playing the role of Emma Carter in Playing House, a show she also co-created.
As a film actress, she has appeared in The Goods: Live Hard, Sell Hard., She’s Out of My League, Life As We Know It, Bridesmaids, Wanderlust, The Dictator, and Afternoon Delight.